Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.
A major challenge for the application of RNA- or DNA-oligonucleotides in biotechnology and molecular medicine is their susceptibility to abundant nucleases.One intriguing possibility to tackle this problem is the COMPASS use of mirror-image (l-)oligonucleotides.For aptamers, this concept has successfully been applied to even develop therapeutic age